Selected by international critics as one of the world's top bass players and recognised for her «great intensity and exceptional technique». Uxía Martinez Botana was the first principal double Bass at the age of 23 of the Grammy Award Winner Kremerata Baltica, under the direction of Gidon Kremer, working with soloists such as Martha Argerich, Emmanuel Pahud, Khatia Buniatishvili, Daniel Baremboin, Mario Brunello, Mikhail Pletnev, Heinrich Schiff, and many other renowned artists. Since January 2016 she has been the principal Double Bass of the Weinberger Kammerorchester (Zurich) under Gábor Takács-Nagy's direction and the Brussels Philharmonic's principal double bass until 2020. She also became a member and solo double bass in 2019 at the Oxford Philharmonic until nowadays.

Other work with orchestras includes The Royal Concertgebouw Orchestra, the Netherlands Philharmonic, the Budapest Festival Orchestra under the direction of Ivan Fischer, and guest principal double bass at the Royal Scottish National Orchestra, Scottish Chamber Orchestra, and Belgium National Orchestra. She is also a Double Bass professor at the ESMUC College of Music of Catalonia in Barcelona (Spain) and a guest professor at the foundation Barenboim-Said. In 2021 She joined as well the Stauffer Center Academy for strings, in Cremona (Italy) together with other renowned artists such as Sol Gabetta, Michael Barenboim, Lisa Batiashivili, Daniel Hope, Julian Rachlin, Lawrence Power, Antoine Tamestit, Steven Isserlis, Mischa Maisky, Alissa Weilestein.